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Tryptophan Metabolism in Cardiometabolic Diseases: Focus on the Kynurenine Pathway

3.4 Inducible modeling systems Knock-in GEMMs for BRAF V600E -mutated gliomas are alternative models that involve conditional and inducible systems such as the Cre-loxP system to allow the expression of BRAF V600E under the control of the endogenous promoter and enhancer sequences in a cell-specific or time-specific manner upon the activation of Cre recombinase (57, 121), which can be induced by delivering either tamoxifen or Cre-expressing viruses such as adeno-associated viruses and adenoviruses (111)

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these characteristics together constitute a major risk of CVD (38)