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Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes | Scientific Reports

Interestingly, the authors found that both compounds 60 and 61 exhibited promising PK parameters, but compound 61 was inactive when evaluated for vivo efficacy in an acute TB infection mouse model

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For instance, the v6 splice variant of the hyaluronan receptor CD44 links c-MET signaling to the actin cytoskeleton via GRB2 and the ezrin, radixin and moesin (ERM) family of proteins in order to recruit SOS, which then amplifies RAS-ERK signaling [Orian-Rousseau et al

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