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The 3-D cell design was made by culturing cells (2 × 105-- 1.0 × 106) with high glucose DMEM supplemented with 30% bovine collagen solution over night

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The pain arises either directly from the disease, through invasion or compression of neural structures including spinal nerves, plexuses, and peripheral nerves, or from a consequence of oncological therapies, with one large study attributing pain to the cancer itself in 92.5% of severe cases and to treatment in 20.8% [138]