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reacts with O-methylisourea in a nucleophilic substitution reaction with the expulsion of methanol to form a guanidino group (has 3 N attached to C, nidi) reacts with fluorodinitrobenzene (FDNB or Sanger's reagent) or trinitrobenzenesulfonate (TNBS, as we saw with the reaction with phosphatidylethanolamine) in a nucleophilic aromatic substitution reaction to form 2,4-DNP-lysine or TNB-lysine

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Likewise, the mRNA of inflammatory mediators (iNOS, IL-6, IFNγ and TNF-α) are inhibited, with increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [19]