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van Ophoven, A., Rossbach, G., Pajonk, F

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Specifically, ZDHHC6 significantly promotes the activation initiation of the TLR signaling pathway by mediating the palmitoylation modification of MYD88 and TLR2, whereas ZDHHC3/5/7 are involved in the activation phase of the inflammatory response by regulating the membrane localization and conformational changes of effector molecules such as STING, NLRP3, and GSDMD