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In hepatocarcinoma, anti-apoptotic miRNAs like miR-21, miR-221/222, and miR-155 are overexpressed, leading to the downregulation of tumor suppressor genes like phosphatase and tensin homolog deleted on chromosome ten ( PTEN ), cyclin-dependent kinase inhibitor 1B ( DKN1B)/p27 , cyclin-dependent kinase inhibitor 1C ( CDKN1C )/ p57 , and toll-like receptor 3 (TLR3)
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