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Glutathione peroxidase‐1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice - Chu - 2020 - Aging Cell - Wiley Online Library

Chronic inflammation, driven by immune cell infiltration (macrophages, T cells, B cells) and pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), activates signaling pathways such as NF-κB and MAPK, promoting disc cell apoptosis and extracellular matrix (ECM) degradation (Figure 1)

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