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Glutathione-s-transferase enzymes role in detoxification
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In the liver, ALKBH5-mediated demethylation of TIR domain-containing adaptor protein (TIRAP) mRNA activates NF-κB and c-Jun N-terminal Kinase/Mothers Against Decapentaplegic Homolog 2 (JNK/Smad2) signaling, thereby promoting radiation-induced hepatic fibrosis
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