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4 Glutaminolysis in autoimmune diseases Under normal conditions, the activity of T cells is controlled by immune tolerance mechanisms that distinguish between autologous and nonautologous components and specifically recognize and react against pathogens ( 4.1 Systemic lupus erythematosus Systemic lupus erythematosus (SLE) is defined as a chronic, recurrent autoimmune disease with recurrent episodes of tissue inflammation and severe multiorgan damage mediated by the body’s autoimmunity (57–59)
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