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applied a cyanoacrylamide warhead to the peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation inhibitor to induce a reversible covalent bond with Cys285 in helix H3 of the PPARγ ligand-binding domain and successfully demonstrated the reversible covalent inhibition of the cyanoacrylamide moiety through mass spectrometry and X-ray crystallography studies (Fig
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