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glutathione synthesis mitochondria Mitochondrial in Cellular Redox Homeostasis and Disease Manifestation Mitochondrial dysfunction

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Apart from catalyzing the conjugation of carcinogenic electrophiles to GSH, the ฮฑ-class GSTs (GSTA1-1 and GSTA2-2) attenuate LPO by catalyzing the GSH-dependent reduction of phospholipid hydroperoxides and fatty acid hydroperoxides through its Se-independent glutathione-peroxidase activity, thereby terminating the auto-catalytic chain of LPO reactions resulting in decreased formation of 4HNE (Zhao et al., 1999

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Abstract Type 2 diabetes mellitus (T2DM) is marked by chronic hyperglycemia, gradually worsening ฮฒ-cell failure, and insulin resistance

glutathione synthesis mitochondria Mitochondrial in Cellular Redox Homeostasis and Disease Manifestation Mitochondrial dysfunction

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