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In a mouse model of experimental autoimmune encephalomyelitis (EAE), a selective NLRP3 inflammasome inhibitor, MCC950 significantly reduces astrogliosis in the cortex, corpus callosum, hippocampus, and white matter tract of mouse brain (Hou et al., 2023)
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ROS including superoxide anions (O 2 •– ), hydroxyl radicals (OH • ) and hydrogen peroxide (H 2 O 2 ) are produced by endothelial cells, inflammatory cells and the mitochondrial electron transport system
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