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Also, the concentrations of glutathione disulfide (GSSG), a marker of intracellular ROS formation, increase substantially with toxic APAP administration to mice (52
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Importantly, this C-terminal truncation is specific for cyclin D-Cdk4,6 complexes and does not affect the phosphorylation of Rb by cyclin E-Cdk2, cyclin A-Cdk2, and cyclin B-Cdk1 complexes (Figures 1C, 1F, and S2H)
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