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From the binding mode shown in Fig 5 , it can be observed that coumarin derivative 5g forms nonpolar van der Waals interactions interactions with amino acid residues Ile104, Val35, and Tyr108 at distances 3.6, 3.65, 3.7 and 3.8 Å, respectively
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Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity
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