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Microbially produced bile acids are associated with increased IgG autoantibodies and poorer mental wellbeing in fibromyalgia | Scientific Reports

PCT, proximal convoluted tubules

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The latest research indicates that I3A not only sustains lung epithelial barrier function through AhR receptor activation and IL-22 secretion stimulation but also inhibits HDAC5/6, resulting in the inactivation of the NF-κB/NLRP3 signaling pathway and the subsequent reduction of inflammatory factor expression (66)