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For this reason, QUIN increase in cells can happen only transiently under specific circumstances, not only in neurons but also, for instance, in hepatocytes (50): under physiological conditions, TRP catabolism goes mainly toward ATP formation and only a minor portion leads to QUIN or NAD + accrual (51)

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This non-chelating structure ( 3 ) (Scheme 1) agrees with that previously proposed for glutathione coordination to metals such as lead and mercury [26]