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Peripheral neuropathy involves nerve damage that can cause numbness, tingling, pain, and mild muscle weakness in the legs and, sometimes, the arms. There are more than 200 causes of peripheral neuropathy, but #

A few common symptoms associated with B12 deficiency are: Fatigue General weakness Irritability Numbness / Tingling Pale Skin Memory / Forgetful B12 shots deliver vitamin B12 directly into muscle tissue to boost energy levels, improve brain function, support red blood cell formation, and maintain healthy nerve cells throughout the body

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As was pointed out, there is no toxicity without protein binding but there can be protein binding without toxicity [39]