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Furthermore, they showed that endogenous H 2 S effectively deactivated IKKβ by sulfhydrating Cys179 of IKKβ to suppress NF-κB pathway activation, ultimately attenuating pulmonary artery ECs inflammation in PAH (Zhang et al., 2019)
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Consequently, MSU crystals can shift local inflammation from a transient defense mechanism to ongoing tissue remodeling through the activation of inflammatory corpuscles and the programmed response of immune cells
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