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For instance, thyroid cancer is associated with the increased presence of Clostridiaceae , Neisseria , and Streptococcus , whereas in patients with thyroid nodules, a relative increase of Streptococcus and Neisseria compared to healthy controls was observed (235)
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Together, these events upregulate glucose uptake and glycolysis, leading to the accumulation of lactate—produced by both tumor cells and TAMs—in the tumor microenvironment ( Figure 3 )
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