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Substance/medication-induced psychotic disorder, although not a primary psychotic disorder, but caused by substance intoxication/withdrawal, can convert into more serious burden with the expected transition from substance/medication-induced psychotic disorder into schizophrenia is 25% with the most important factors triggering transition including abuse of cannabis (34%), hallucinogens (26%), amphetamines (22%), opioids (12%), alcohol (10%), and sedatives (9%) (Murrie et al., 2019)

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FDA scientists flagged the telomerase activation itself as a potential safety concern given theoretical carcinogenicity implications, a concern that the longevity research community would characterize as unproven and speculative