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Oral DMTs: An alternative to injectable therapies In 2010, fingolimod (Gilenya ® , Novartis, Switzerland) was the first oral MS DMT approved by the FDA, with teriflunomide (Aubagio ® , Genzyme, France) following in 2012 and cladribine (Mavenclad ® , Merck, Germany) in 2017 approved by the EMA
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After menopause, the decline in estrogen, accompanied by a decrease in HDL-C and an increase in LDL-C, exacerbates oxidative stress-related depressive symptoms (40)
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