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Methionine, inositol, and choline are not typically supplemented orally at therapeutic doses in isolation, so the MIC component still adds value even if B12 is covered

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In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)