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Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium
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However, in the presence of RanBP1, the trimeric importin β:Ran-GTP: RanBP1 complex becomes susceptible to GTP hydrolysis, which additionally requires the importin β binding (IBB) domain of importin α1 in vitro 33,34
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