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Normal cellular concentration of SAMe can inhibit MAT II strongly (IC50 = 60 μM), and minimally MAT I (IC50 = 400 μM) and even stimulates MAT III up to 8-fold at 500 μM SAMe [8,9,10,11]
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This invasion is responsible for killing and injuring the intestinal cells, particularly goblet cells and Paneth cells
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