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Substrate Profiling of Glutathione S‐transferase with Engineered Enzymes and Matched Glutathione Analogues - Feng - 2014 - Angewandte Chemie International Edition - Wiley Online Library

In studies of GPX5 knockout mice, we deduced that GPX5 is a way to maintain the integrity of sperm DNA function by removing excess H 2 O 2 , and these mice did not exhibit significant defects in the epididymis and sperm cells ( 2 O 2 scavengers was detected (Noblanc et al., 2012), proving that after SNGPX4 and GPX5 double knockouts, the epididymal tissues of mice produced oxidative stress responses, indicating that SNGPX4 and GPX5 play a role in maintaining the normal structure of the sperm nucleus in the epididymal tissue (Noblanc et al., 2012)

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doi: 10.1155/2022/6839356, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Komiya Y., Shimomura Y., Higurashi T., Sugi Y., Arimoto J., Umezawa S., et al