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Both schizophrenia and vascular dementia involve cholinergic dysfunction contributing to cognitive impairment, but schizophrenia is mainly associated with α7 nicotinic acetylcholine receptor (nAChR) abnormalities in frontal–cingulate regions, whereas VaD predominantly affects α4β2 nAChRs in hippocampal and subcortical structures (179)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Liu T., Kong X., Qiao J., Wei J
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