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Advances in metabolomics and nutrigenomics suggest that specific patient subpopulations may realize the greatest benefit, indicating a move away from generalized supplementation toward a more targeted adjunctive therapy integrated with evidence-based cardiovascular care (Figure 1), distinguishing well-established clinical evidence from hypothesis-generating findings, and highlights emergent areas where nutraceuticals may reshape preventive and therapeutic cardiology

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High GH and high IGF-I One of the most well-described primary GH disorders of high GH and high IGF-I is acromegaly (66)