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It neutralizes lipid peroxidation chain reactions by donating a hydrogen atom to lipid peroxyl radicals, forming relatively unreactive Ξ± tocopheroxyl radicals
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76 Mutations in DNMT3A have been reported in approximately 20% of patients with acute myeloid leukemia (AML) 77 and in 8% of patients with myelodysplastic syndromes (MDS), 78 with DNMT3A mutations being associated with a less optimistic prognosis for both diseases
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