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Disclosure of interest: No ONGOING TRIALS 1027 Efficacy of Cerebrolysin Treatment as an add-on Therapy to Mechanical Thrombectomy – preliminary results of WIM-Cerebrolysin Study Jacek Staszewski* 1 , Piotr Piasecki 2 , Aleksander Dębiec 1 , Katarzyna Agnieszka Gniadek Olejniczak 3 , Artur Maliborski 4 1 Military Institute of Medicine - National Research Institute, Clinic of Neurology, Warsaw, Poland , 2 Military Institute of Medicine-National Research Institute, Interventioanl Radiology Department, Warsaw, Poland , 3 Military Institute of Medicine-National Research Institute, Rehabilitation Clinic, Warsaw, Poland , 4 Military Institute of Medicine-National Research Institute, Radiology Department, Warsaw, Poland Background and aims: We hypothesized that adding Cerebrolysin (30 ml iv od within 8h of onset and followed until day 21) in consecutive 50 acute ischemic stroke (AIS) patients (with baseline small ischemic core, good collateral status, effective reperfusion, symptoms of cortical damage) may increase the effectiveness and safety of mechanical thrombectomy (MT) in the early recovery phase (90 days) comparing to 50 historical control group (CG) matched for age and sex fulfilling the same inclusion criteria by initiating cytoprotective effects and preventing reperfusion injury and delayed cell death

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Regulation of the phagocyte NADPH oxidase by Rac GTPase