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Intranasal delivery exploits the direct olfactory route to bypass hepatic first-pass metabolism and achieve rapid CNS peptide exposure, a mechanism well documented in the published research literature for both Semax and Selank specifically
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reported elevated AAV vector expression during inflammatory episodes, while synthetic promoters responsive to proinflammatory signals provide a promising platform for integrating CRISPR-Cas9 and other editing tools (184, 185)
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