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Stage 4: Severe Disability Symptoms: Significant weakness and muscle atrophy Limited mobility Need for assistive devices for mobility Impact: Daily tasks require assistance, including mobility Stage 5: Progressive Disability Symptoms: Extreme difficulty in mobility Weakness in the neck and difficulty holding up the head Difficulty swallowing and speaking Impact: The person may require a wheelchair for mobility and assistance with most daily activities Stage 6: Bedridden Stage Symptoms: Severe weakness in legs and arms Inability to speak and swallow Respiratory issues Impact: Total dependency on caregivers for daily activities, and often requires hospital-grade medical equipment at home or in a specialized care facility Stage 7: Terminal Stage Symptoms: Severe respiratory issues Major cognitive impact Failure of most bodily functions Impact: The focus shifts to palliative care to relieve symptoms and improve quality of life

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In mice, topical application of BITC also ameliorated the TPA-induced swelling in the ears (model for inflammation diseases, including psoriasis) diminishing the expressions of iNOS and COX2 (145)