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officinalis fruits such as gallotannins, particularly 7- O -galloyl-D-sedopheptulose ( 120 ), and morroniside ( 8 ) inhibited AGE formation or inhibited expression of receptors for AGEs (Yamabe et al., 2009

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Type 1 or type 2 errors in studies of TSPO-binding PET radioligand uptake in brain could potentially be explained by the following methodological confounds: Standard neuroimaging techniques were not designed for brainstem study The first-generation radioligand PK11195 has high non-specific binding and low signal-to-background ratio PET signal calculated with an anatomical reference brain region relies on equal radioligand uptake in that region across cases and controls Radioligand access to brain is modified by general metabolism, which can differ across cases and controls Activated peripheral immune cells bind radioligand and can differ in quantity across cases and controls A single nucleotide polymorphism (SNP) in the TSPO gene causes differential radioligand binding Use of healthy controls harms discriminant validity Here, we will address each of these issues and describe solutions