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Disruption of its function has been identified in several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and prion diseases, as well as in amyotrophic lateral sclerosis (ALS)
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For example, Lactiplantibacillus plantarum precolonization led to the upregulation of 12-oxo phytodienoic acid and downregulation of antioxidants and lipid peroxidation products, indicating reduced oxidative stress and a shift in host metabolic state that may underlie its protective effects against caries (Wu et al., 2025)
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