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PA/PAE prodrugs release drugs from the polymer backbone by hydrolysis, and thus are inherently biodegradable and can be used as drug eluting implant that does not require surgical removal[157]
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Reduced cardiac output, cerebral blood flow (CBF), and blood-brain barrier (BBB) integrity, along with heightened sympathetic nerve and renin-angiotensin-aldosterone system (RAAS) activity, contribute to cognitive impairment in heart failure [11-14]
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