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In response to increased Ca 2+ , NFAT is dephosphorylated by calmodulin-dependent calcineurin phosphatase, resulting in its translocation to the nucleus and subsequent contribution to the expression of genes which, in the particular case of muscle fibers, include Myosin heavy-chain-1 (MHC-I), myoferlin, utrophin A, and Myocyte-specific enhancer factor 2C (MEF2C) [134,135,136]