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Routes of administration and dosages of commonly used estrogens Estrogen Route Dosage Natural and equine estrogens Conjugated equine estrogens Oral 0.3-2.5 mg/day Intramuscular 25 mg/day Intravenous 25 mg/day Vaginal 2-4 g/day Piperazine estrone sulfate Oral 0.625-2.5 mg/day Vaginal 2-4 g/day Estradiol Patch 0.05-0.1 mg every 3-4 days Vaginal 1-4 g/day Micronized, valerate Oral 1-2 mg/day Valerate Intramuscular 10 mg/month Cypionate Intramuscular 1-5 mg/month Synthetic estrogens Ethinylestradiol Oral 20-50 µg/day Mestranol Oral 50-100 µg/day Diethylstilbestrol Oral 1-5 mg/day Quinestrol Oral 0.1 mg/day Table 17