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In the context of pro-inflammatory macrophage activation, methionine sulfoxide reductase B1 (MsrB1) effectively reduces oxidized methionine and protects GAPDH from ROS, consequently sustaining GAPDH activity for glycolysis
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Its unusual gamma-glutamyl bond resists most peptidases, but gamma-glutamyltransferase on the intestinal brush border and in tissues cleaves it
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