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As the microbiome is developed alongside brain development from pregnancy until the first few years after birth, it has been postulated that an imbalance in the gut microbiome during the critical neurodevelopmental phase can influence brain maturation processes, including the establishment of the blood-brain barrier, neurogenesis, maturation of microglia and myelination, by triggering aberrant immune activation and systemic inflammation, thereby leading to symptoms associated with major neuropsychiatric disorders [84]

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