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TIMP-1, a widely distributed glycoprotein, disrupts the balance between collagen synthesis and degradation within the extracellular matrix by inhibiting the activity of matrix metalloproteinases (MMPs), specifically MMP-1, MMP-3, and MMP-9

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Another strategy of drug modification for bypassing the BBB is conjugation to bioactive molecules, either those that are normally transported into the CNS by specific transport proteins or some that enter the CNS via receptor-mediated endocytosis by cerebrovascular endothelium