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Signaling pathways modulated by glutathione NRF2/KEAP1 antioxidant response: Oxidation or S‑glutathionylation of Keap1 cysteines impairs Nrf2 ubiquitination, allowing Nrf2 stabilization, nuclear translocation, and induction of ARE-driven genes, including GCL subunits, the cystine/glutamate antiporter xCT, and GST isoforms—creating a feed-forward elevation of GSH synthesis and conjugation capacity
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As the p53 is not attached to the natural FOXO4 (which holds it in the nucleus), it moves to the mitochondria and triggers apoptosis
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