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These findings indicate not passive ROS accumulation, but a state of sustained oxidative stress, in which increased SOD2 likely reflects a compensatory response to rising superoxide levels (Felgueiras et al., 2022)

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In 2018, Jiang discovered that viral infections lead to a significant increase in the cytoplasmic concentration of Mn 2+ , and there was a close dependency between Mn 2+ and the cGAS-STING pathway [89], which has aroused the interest in Mn 2+ for immunotherapy