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Melatonin is known to alleviate oxidative stress-triggered calcium signaling through the expression of transient receptor potential (TRP), melastatin 2 (TRPM2), and TRP vanilloid type 1 (TRPV1) in the hippocampus (Kahya, Naziroglu, & Ovey, 2017)
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The link between GSTs and the MAP kinase pathway provides a rationale as to why in many cases the drugs used to select for resistance are neither subject to conjugation with GSH, nor substrates for GSTs
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