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In male Wistar rats, sucralose (1.5%) exerted the highest effect on stimulating PPARα expression and CPT-1 compared with other sweeteners (sucrose, fructose, glucose, steviol glycosides, brown sugar, honey, and steviol glycoside+sucrose), and to that of untreated mice (plain water) (92)

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Neuropathological examination of Menkes patient brains shows widespread atrophy of both white and grey matter and neuronal loss that is most pronounced in the cerebral cortex but also affects the hippocampus, striatum, hypothalamus, and thalamus to variable degrees (Zlatic et al., 2015)