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Re-expression of GPx3 inhibits the Erk-dependent activation of NF-κB, which leads to cyclin B1 inhibition and G2/M cell cycle arrest [86], as well as inhibition of epithelial-mesenchymal transition (EMT) by downregulating the Erk-NF-κB-SIP1 signaling axis [87,88]
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Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue
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