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When to Speak to Your GP or Pharmacist Contact your GP or prescribing clinician if you experience: Severe or persistent nausea and vomiting that prevents you from taking your regular medications or staying hydrated New or worsening reflux symptoms despite taking omeprazole as prescribed Severe abdominal pain , particularly if constant or radiating to your back, which could indicate pancreatitis (a rare but serious side effect of GLP-1 agonists) [10] [11] Pain in the upper right abdomen, fever, jaundice, pale stools or dark urine , which could indicate gallbladder problems (more common with GLP-1 agonists) [12] [13] Difficulty swallowing or a sensation of food sticking in your chest or throat Unexplained weight loss beyond what is expected with Wegovy, or inability to maintain adequate nutrition Signs of gastrointestinal bleeding , including black tarry stools, vomiting blood, or severe anaemia symptoms (extreme fatigue, breathlessness, pale skin) Symptoms of low magnesium if you have been on omeprazole long-term, such as muscle cramps, tremors, irregular heartbeat, or seizures Seek urgent help via NHS 111 or call 999 for severe abdominal pain, significant vomiting of blood, large amounts of black tarry stools, or if you feel faint or extremely unwell

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Lastly, applications of GST inhibitors in targeting cell signaling pathways and intracellular biological processes are discussed, and the potential for disease treatment is prospected