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a method for increasing circulating glutathione levels includes orally administering to an individual in need thereof about 100 to about 400 milligrams of S-acetyl-glutathione (SAG) encapsulated in one or more acid-resistant, delayed-release gel capsules

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In 2011, 70% of the procedures involved chondroplasty (smoothing the defect by removing loose strands of cartilage), 28% involved microfracture or subchondral drilling (techniques used to release marrow elements), and only 2% involved the use of advanced cartilage restoration techniques (osteochondral autograft transfer, ACI)