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Example 162 3-(4-(4-Bromophenyl)thiazol-2-yl)-2-(trifluoromethyl)thieno[3,2-d]pyrimidin- 4(3H)-one (XH216-58p1) 1 H NMR (400 MHz, Chloroform-d) ⁇ 8.04 – 7.93 (m, 1H), 7.82 – 7.70 (m, 3H), 7.60 – 7.53 (m, 3H)

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The saffron is well-dosed at 30mg, but the others appear in a proprietary blend totaling just 200mg, while they together would need to total around at least 700mg to have a chance of being therapeutically effective.62 63 64 Essentials’ longevity blend is an even more egregious example, as it totals just 100mg while its top-listed ingredients aren’t clinically relevant until they hit 100–250mg each.92 93 At the same time, much of Essentials’ formulation is dosed just fine