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At the level of predicted amino acid sequence, identity between classes is typically less than 30%, and even within classes identity can be as low as 30%

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The mTOR signaling can be activated by three board categories of instructive signals, encompassing environmental cues (e.g., growth factors and immunoregulatory factors), immune signals (e.g., co-stimulation, antigens, and cytokines), and nutrients (e.g., essential amino acids and glucose) (98)