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Still, our data raise the possibility of several additional nodes of regulation of the CIA in response to cysteine limitation that are worthy of further exploration, including inhibition of cytosolic cluster synthesis due to cysteine insufficiency, restriction of mitochondrial cluster export, or differential cluster integration into recipient proteins through the regulation of the chaperone-based trafficking system 79

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This is the reason why vegans and vegetarians are more likely to be deficient in vitamin b12