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Through allosteric coupling within a ternary complex of ligand-receptor-transducer [8], ligand binding in the ECD stabilizes receptor conformation(s) that are transmitted to transducer-coupling motifs on the intracellular face of the receptor to influence signal transduction [9]

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Expanding these analyses to additional ALS models and incorporating functional validations will therefore be essential to fully assess the therapeutic potential of our FM19G11-based nanotechnology approach across diverse ALS subgroups and phenotypes

Carnitine is a naturally occurring amino acid derivative that plays a crucial role in energy production by transporting fatty acids into the mitochondria